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Centre of Mathematical Sciences Seminar Series
Date: 7 May 2010 (Friday)
Time: 2 - 3 pm
Venue: Meeting Room, Block PD, UTAR PJ Campus
Speaker: Dr. Tan Aik Choon, University of ColoradoCentre of Mathematical Sciences Seminar Series
Date: 7 May 2010 (Friday)
Time: 2 - 3 pm
Venue: Meeting Room, Block PD, UTAR PJ Campus
Title: Translational Bioinformatics: From Bytes to Bedside and Back
Abstract:
Cancer is driven by multiple genetic and epigenetic alterations, including changes in DNA sequence, aberrations of copy number, abnormalities of chromosomes, and modification of DNA methylation. Today's powerful and high-throughput technologies have enabled researchers: (1) to characterize these genomic abnormalities, which have largely been studied in isolation, within individual cancer genome; and (2) to survey these changes across large numbers of cancer genomes in great detail. Two major findings revealed from these studies: human tumors are heterogeneous and genomic alterations occur in specific pathways to drive cancer development and progression. These findings have major implication to oncology drug development and cancer treatment. In this talk, I will give an overview on how to develop and employ bioinformatics to integrate these massive data from diverse sources and translate them into meaningful clinical applications.
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Dear all,
This week CMS seminar is from Dr. Tan Aik Choon of University of Colorado.
Aik Choon Tan, Ph.D., is an Assistant Professor of Bioinformatics at the Division of Medical Oncology, Department of Medicine, University of Colorado Denver School of Medicine. He also has a secondary appointment at the Department of Biostatistics and Informatics, Colorado School of Public Health. He is a member of the University of Colorado Cancer Center, Developmental Therapeutics Program and a faculty member of the Head and Neck Cancer Research Program.
Aik Choon's research interest is to translate the basic research into clinical trials for personalized cancer treatment by 1) developing novel bioinformatics approaches to integrate and interpret high-throughput and complex biological data sources for biomarker discovery, and 2) devising new computational strategies to identify aberrant signaling and metabolic pathways in tumors. He is the Director of the Translational Bioinformatics and Cancer Systems Biology laboratory (The Tan Lab). He is also the coordinator of the bioinformatics and biostatistics group of investigators working in developing new algorithms and statistical methods to analyze next-generation sequencing data at the UCD School of Medicine.
Aik Choon graduated from the University of Technology Malaysia with First Class Degree in Bioprocess/Chemical Engineering (2000). He earned his Ph.D. in Computer Science/Bioinformatics from the University of Glasgow in 2004. Subsequently, he received his post-doctoral training at the Johns Hopkins University Whiting School of Engineering (2004 – 2007) and at the Sidney Kimmel Cancer Center at the Johns Hopkins University School of Medicine (2007 – 2009) before he joined the faculty of the University of Colorado in 2009.
He is an editorial board member of the Cancer Informatics journal, and he is a regular peer reviewer for bioinformatics related journals. He is a member of the International Society of Computational Biology (ISCB), the American Association for Cancer Research (AACR) and the American Society of Clinical Oncology (ASCO).
Thank you very much.
regards,
Kheng
----
Dr. Goh Yong Kheng
Assistant Professor / Deputy Dean
Faculty of Information & Communication Technology
University of Tunku Abdul Rahman
13, Jalan 13/6, 46200 Petaling Jaya, Selangor, MALAYSIA
Tel: 03-7955-1511 Ext 105
Abstract:
Cancer is driven by multiple genetic and epigenetic alterations, including changes in DNA sequence, aberrations of copy number, abnormalities of chromosomes, and modification of DNA methylation. Today's powerful and high-throughput technologies have enabled researchers: (1) to characterize these genomic abnormalities, which have largely been studied in isolation, within individual cancer genome; and (2) to survey these changes across large numbers of cancer genomes in great detail. Two major findings revealed from these studies: human tumors are heterogeneous and genomic alterations occur in specific pathways to drive cancer development and progression. These findings have major implication to oncology drug development and cancer treatment. In this talk, I will give an overview on how to develop and employ bioinformatics to integrate these massive data from diverse sources and translate them into meaningful clinical applications.
===================================================
Dear all,
This week CMS seminar is from Dr. Tan Aik Choon of University of Colorado.
Aik Choon Tan, Ph.D., is an Assistant Professor of Bioinformatics at the Division of Medical Oncology, Department of Medicine, University of Colorado Denver School of Medicine. He also has a secondary appointment at the Department of Biostatistics and Informatics, Colorado School of Public Health. He is a member of the University of Colorado Cancer Center, Developmental Therapeutics Program and a faculty member of the Head and Neck Cancer Research Program.
Aik Choon's research interest is to translate the basic research into clinical trials for personalized cancer treatment by 1) developing novel bioinformatics approaches to integrate and interpret high-throughput and complex biological data sources for biomarker discovery, and 2) devising new computational strategies to identify aberrant signaling and metabolic pathways in tumors. He is the Director of the Translational Bioinformatics and Cancer Systems Biology laboratory (The Tan Lab). He is also the coordinator of the bioinformatics and biostatistics group of investigators working in developing new algorithms and statistical methods to analyze next-generation sequencing data at the UCD School of Medicine.
Aik Choon graduated from the University of Technology Malaysia with First Class Degree in Bioprocess/Chemical Engineering (2000). He earned his Ph.D. in Computer Science/Bioinformatics from the University of Glasgow in 2004. Subsequently, he received his post-doctoral training at the Johns Hopkins University Whiting School of Engineering (2004 – 2007) and at the Sidney Kimmel Cancer Center at the Johns Hopkins University School of Medicine (2007 – 2009) before he joined the faculty of the University of Colorado in 2009.
He is an editorial board member of the Cancer Informatics journal, and he is a regular peer reviewer for bioinformatics related journals. He is a member of the International Society of Computational Biology (ISCB), the American Association for Cancer Research (AACR) and the American Society of Clinical Oncology (ASCO).
Thank you very much.
regards,
Kheng
----
Dr. Goh Yong Kheng
Assistant Professor / Deputy Dean
Faculty of Information & Communication Technology
University of Tunku Abdul Rahman
13, Jalan 13/6, 46200 Petaling Jaya, Selangor, MALAYSIA
Tel: 03-7955-1511 Ext 105
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